Vetenskapliga artiklar om borrelia, TBE och co-infektioner
700 st granskade vetenskapliga artiklar om borrelia och co-infektioner från ILADS här
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Spotted Fever Rickettsioses in
Sweden
Aspects of Epidemiology, Clinical Manifestations and
Co-infections
ANDERS LINDBLOM
http://uu.diva-portal.org/smash/get/diva2:956560/FULLTEXT01.pdf
Ticks Tick Borne Dis. 2018 Oct 28. pii: S1877-959X(18)30297-8. doi: 10.1016/j.ttbdis.2018.10.007. [Epub ahead of print]
High seroprevalence of Babesia antibodies among Borrelia burgdorferi-infected humans in Sweden.
Svensson J1, Hunfeld KP2, Persson KEM3.
https://www.ncbi.nlm.nih.gov/pubmed/30389326?fbclid=IwAR1GuLgW0ovxKFozXcrcclD--CbADHF8nJOfDAENcTwHlbisARRpJpEf8XY
Co-infection of Ticks: The Rule Rather Than the Exception
Sara Moutailler, Claire Valiente Moro, Elise Vaumourin, Lorraine Michelet, Florence Hélène Tran, Elodie Devillers, Jean-François Cosson, Patrick Gasqui, Van Tran Van, Patrick Mavingui, Gwenaël Vourc’h, Muriel Vayssier-Taussat
Published: March 17, 2016http://dx.doi.org/10.1371/journal.pntd.0004539
Evaluating polymicrobial immune responses in patients suffering from tick-borne diseases
Kunal Garg, Leena Meriläinen, Ole Franz, Heidi Pirttinen, Marco Quevedo-Diaz, Stephen Croucher & Leona Gilbert
Scientific Reportsvolume 8, Article number: 15932 (2018)
https://www.nature.com/articles/s41598-018-34393-9?fbclid=IwAR2suvR8Fd87vtctaRdDWrqc60PTeCgL4F4Sh6F1b1RyatNPQEfX8PkzTjU
Diagnosing Borreliosis
Sally J. Cutler,1 Nataliia Rudenko,2 Maryna Golovchenko,2 Wibke J. Cramaro,3
Josiane Kirpach,3 Sara Savic,4 Iva Christova,5 and Ana Amaro6
Guidelines for the Detection of Rickettsia spp.
Ara´ nzazu Portillo,1 Rita de Sousa,2 Sonia Santiba´ n˜ ez,1 Ana Duarte,3 Sophie Edouard,4
Isabel P. Fonseca,3 Ca´tia Marques,3 Marketa Novakova,5,6 Ana M. Palomar,1 Marcos Santos,3
Cornelia Silaghi,7 Laura Tomassone,8 Sara Zu´ quete,3 and Jose´ A. Oteo1
Guidelines for the Direct Detection of Anaplasma spp. in Diagnosis and Epidemiological Studies
Cornelia Silaghi,1,* Ana Sofia Santos,2,* Jacinto Gomes,3 Iva Christova,4 Ioana Adriana Matei,5
Gernot Walder,6 Ana Domingos,7 Lesley Bell-Sakyi,8 Hein Sprong,9 Friederike D. von Loewenich,10
Jose´ A. Oteo,11 Jose´ de la Fuente,12,13 and J. Stephen Dumler14,15
Recent study on canine vector-borne zoonoses in southern Slovakia - serologic survey.
Čabanová V, Pantchev N, Hurníková Z, Miterpáková M.
Acta Parasitol. 2015 Dec 1;60(4):749-58. doi: 10.1515/ap-2015-0107.
PMID: 26408601
Coexistence of Borrelia burgdorferi s.l. genospecies within Ixodes ricinus ticks from central and
eastern Poland.
Sytykiewicz H, Karbowiak G, Chorostowska-Wynimko J, Szpechciński A, Supergan-Marwicz M, Horbowicz M, Szwed M,
Czerniewicz P, Sprawka I.
Acta Parasitol. 2015 Dec 1;60(4):654-61. doi: 10.1515/ap-2015-0093.
PMID: 26408587
Borrelia burgdorferi sensu lato and co-infections with Anaplasma phagocytophilum and Rickettsia
spp. in Ixodes ricinus in Hamburg, Germany.
May K, Jordan D, Fingerle V, Strube C.
Med Vet Entomol. 2015 Dec;29(4):425-9. doi: 10.1111/mve.12125. Epub 2015 Jun 19.
PMID: 26096626
Molecular survey of tick-borne pathogens in Ixodid ticks collected from hunted wild animals in
Tuscany, Italy.
Ebani VV, Bertelloni F, Turchi B, Filogari D, Cerri D.
Asian Pac J Trop Med. 2015 Sep;8(9):714-7. doi: 10.1016/j.apjtm.2015.07.033. Epub 2015 Jul 29.
PMID: 26433656
Within-host competition between Borrelia afzelii ospC strains in wild hosts as revealed by massively
parallel amplicon sequencing.
Strandh M, Råberg L.
Philos Trans R Soc Lond B Biol Sci. 2015 Aug 19;370(1675). pii: 20140293. doi: 10.1098/rstb.2014.0293.
PMID: 26150659
Infections with Candidatus Neoehrlichia mikurensis and Cytokine Responses in 2 Persons Bitten by
Ticks, Sweden.
Grankvist A, Sandelin LL, Andersson J, Fryland L, Wilhelmsson P, Lindgren PE, Forsberg P, Wennerås C.
Emerg Infect Dis. 2015 Aug;21(8):1462-5. doi: 10.3201/eid2108.150060.
PMID: 26197035
Current Surveys of the Seroprevalence of Borrelia burgdorferi, Ehrlichia canis, Anaplasma
phagocytophilum, Leishmania infantum, Babesia canis, Angiostrongylus vasorum and Dirofilaria
immitis in Dogs in Bulgaria.
Pantchev N, Schnyder M, Vrhovec MG, Schaper R, Tsachev I.
Parasitol Res. 2015 Aug;114 Suppl 1:S117-30. doi: 10.1007/s00436-015-4518-8.
PMID: 26152413
Borrelia miyamotoi Disease in the Northeastern United States: A Case Series.
Molloy PJ, Telford SR 3rd, Chowdri HR, Lepore TJ, Gugliotta JL, Weeks KE, Hewins ME, Goethert HK, Berardi VP.
Ann Intern Med. 2015 Jul 21;163(2):91-8. doi: 10.7326/M15-0333.
PMID: 26053877
Erythema migrans.
Nadelman RB.
Infect Dis Clin North Am. 2015 Jun;29(2):211-39. doi: 10.1016/j.idc.2015.02.001. Review.
PMID: 25999220
Molecular Detection of Fastidious and Common Bacteria as Well as Plasmodium spp. in Febrile and
Afebrile Children in Franceville, Gabon.
Mourembou G, Fenollar F, Socolovschi C, Lemamy GJ, Nzoughe H, Kouna LC, Toure-Ndouo F, Million M, Mbiguino AN,
Lekana-Douki JB, Raoult D.
Am J Trop Med Hyg. 2015 May;92(5):926-32. doi: 10.4269/ajtmh.14-0699. Epub 2015 Mar 23.
PMID: 25802432
Motor rotation is essential for the formation of the periplasmic flagellar ribbon, cellular morphology,
and Borrelia burgdorferi persistence within Ixodes scapularis tick and murine hosts.
Sultan SZ, Sekar P, Zhao X, Manne A, Liu J, Wooten RM, Motaleb MA.
Infect Immun. 2015 May;83(5):1765-77. doi: 10.1128/IAI.03097-14. Epub 2015 Feb 17.
PMID: 25690096
Canine vector-borne infections in Mauritius.
Lee GK, Ignace JA, Robertson ID, Irwin PJ.
Parasit Vectors. 2015 Mar 23;8:174. doi: 10.1186/s13071-015-0790-9.
PMID: 25889893
First arrived takes all: inhibitory priority effects dominate competition between co-infecting
Borreliaburgdorferi strains.
Devevey G, Dang T, Graves CJ, Murray S, Brisson D.
BMC Microbiol. 2015 Mar 7;15:61. doi: 10.1186/s12866-015-0381-0.
PMID: 25887119
Lyme disease update for the general dermatologist.
Godar DA, Laniosz V, Wetter DA.
Am J Clin Dermatol. 2015 Feb;16(1):5-18. doi: 10.1007/s40257-014-0108-2.
PMID: 25589049
Co-feeding transmission in Lyme disease pathogens.
Voordouw MJ.
Parasitology. 2015 Feb;142(2):290-302. doi: 10.1017/S0031182014001486. Epub 2014 Oct 8. Review.
PMID: 25295405
Infectious agents and inflammation in donated hearts and dilated cardiomyopathies related to
cardiovascular diseases, Chagas' heart disease, primary and secondary dilated cardiomyopathies.
Mangini S, Higuchi Mde L, Kawakami JT, Reis MM, Ikegami RN, Palomino SA, Pomerantzeff PM, Fiorelli AI, MarcondesBraga
FG, Bacal F, Ferreira SM, Issa VS, Souza GE, Chizzola PR, Bocchi EA.
Int J Cardiol. 2015 Jan 15;178:55-62. doi: 10.1016/j.ijcard.2014.10.133. Epub 2014 Oct 23.
PMID: 25442238
Historic evidence to support a causal relationship between spirochetal infections and Alzheimer's
disease.
Miklossy J.
Front Aging Neurosci. 2015 Apr 16;7:46. doi: 10.3389/fnagi.2015.00046. eCollection 2015. Review.
PMID: 25932012
Clinical determinants of Lyme borreliosis, babesiosis, bartonellosis, anaplasmosis, and ehrlichiosis in
an Australian cohort.
Mayne PJ.
Int J Gen Med. 2014 Dec 23;8:15-26. doi: 10.2147/IJGM.S75825. eCollection 2015.
PMID: 25565883
Acute diffuse and total alopecia of the female scalp associated with borrelia-infection.
Bhardwaj EK, Trüeb RM.
Int J Trichology. 2015 Jan-Mar;7(1):26-8. doi: 10.4103/0974-7753.153454.
PMID: 25878446
Vetenskapliga artiklar om TBE
Characterization of tick-borne encephalitis (TBE) foci in Germany and Latvia (1997-2000).
Süss J, Schrader C, Abel U, Bormane A, Duks A, Kalnina V.
Int J Med Microbiol. 2002 Jun;291 Suppl 33:34-42.
Microclimate and the zoonotic cycle of tick-borne encephalitis virus in Switzerland.
Burri C, Bastic V, Maeder G, Patalas E, Gern L.
J Med Entomol. 2011 May;48(3):615-27.
Why is tick-borne encephalitis increasing? A review of the key factors causing the increasing incidence of human TBE in Sweden.
Jaenson TG, Hjertqvist M, Bergström T, Lundkvist A.
Parasit Vectors. 2012 Aug 31;5:184. doi: 10.1186/1756-3305-5-184.
Peer Reviewed Evidence of Persistence of Lyme Disease Spirochete
Borrelia burgdorferi and Tick-Borne Diseases
The following is a list of over 700 peer reviewed articles that support the evidence of persistence of Lyme
and other tick-borne diseases. It is organized into different categories—general, psychiatric, dementia,
autism and congenital transmission.
General: Persistence of Lyme Disease Spirochete Borrelia burgdorferi
The following section of references for persistence of Lyme disease (Lyme borreliosis) are listed alphabetically and chronologically:
1. Aalto A, Sjowall J, Davidsson L, Forsberg P, Smedby O. Brain magnetic resonance imaging does not contribute to the diagnosis of
chronic neuroborreliosis. Acta Radiol 2007; 48: 755-762. [white matter hyperintensities or basal ganglia lesions].
2. Abele DC and Anders KH. The many faces and phases of borreliosis. J Am Acad Dermotol 1990; 23:401-410. [chronic Lyme
borreliosis].
3. Aberer E and Klade H. Cutaneous manifestations of Lyme borreliosis. Infection 1991; 19: 284-286. [chronic Lyme borreliosis].
4. Aberer E, Breier F, Stanek G, and Schmidt B. Success and failure in the treatment of acrodermatitis chronica atrophicans skin rash.
Infection 1996; 24: 85-87.
5. Aberer E, Kersten A, Klade H, Poitschek C, Jurecka W. Heterogeneity of Borrelia burgdorferi in the skin. Am J Dermatopathol 1996;
18(6): 571-519.
6. Akin E, McHugh Gl, Flavell RA, Fikrig E, Steere AC. The immunoglobulin (IgG) antibody response to OspA and OspB correlates
with severe and prolonged Lyme arthritis and the IgG response to P35 with mild and brief arthritis. Infect Immun 1999; 67: 173-181.
7. Albert S, Schulze J, Riegel H, Brade V. Lyme arthritis in a 12-year-old patient after a latency period of 5 years. Infection 1999; 27(4-
5): 286-288.
8. Al-Robaiy S, Dihazi H, Kacza J, et al. Metamorphosis of Borrelia burgdorferi organisms―RNA, lipid and protein composition in
context with the spirochete’s shape. J Basic Microbiol 2010, 50 Suppl 1, S5-17.
9. Appel MJG, Allan S, Jacobson RH, Lauderdale TL, Chang YF, Shin SJ, Thomford JW, Todhunter RJ, and Summers BA.
Experimental Lyme disease in dogs produces arthritis and persistent infection. J Inf Dis 1993; 167: 651-664.
10. Åsbrink E, Hovmark A. Successful cultivation of spirochetes from skin lesions of patients with erythema chronicum migrans, Afzelius
and acrodermatis chronica atrophicans. Acta Pathol Microbiol Immunol Sect B 1985; 93: 161-163.
11. Åsbrink E, Hovmark A, and Olsson I. Clinical manifestations of acrodermatitis chronica atrophicans in 50 Swedish patients. Zentralbl
Bakteriol Mikrobiol Hyg A 1986; 26: 253-261. [chronic Lyme borreliosis].
12. Asch ES, Bujak DI, Weiss M, Peterson MGE, and Weinstein A. Lyme Disease: an infectious and postinfectious syndrome. J
Rheumatol 1994; 21 (3): 451-461.
13. Bankhead T and Chaconas G. The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism
that differs from other pathogens. Molecular Microbiology 2007; 65: 1547-1558.
14. Barthold SW, Persing DH, Armstrong AL, and Peeples RA. Kinetics of Borrelia burgdorferi dissemination and evolution of disease
following intradermal inoculation of mice. Am J Pathol 1991; 139: 263-273. [in mice]
15. Barthold SW, deSouza MS, Janotka JL, Smith AL, and Persing DH. Chronic Lyme borreliosis in laboratory mouse. Am J Pathol 1993;
143: 951-971. [in mice]
16. Barthold S. Lyme borreliosis. Chapter 14, In Persistent Bacterial Infections. Edited by J.P. Nataro, M.J. Blaser, and S. CunninghamRundles,
pp 281-304. ASM Press, Washington, D.C.
17. Barthold SW, Hodzic E, Imai DM, Feng S, Yang X, and Luft BJ. Ineffectiveness of tigecycline against persistent Borrelia
burgdorferi. Antimicrob Agents Chemother 2010; 54(2): 643-651. [mice, rats, white-footed mice, hamsters, gerbils, guinea pigs,
rabbits, dogs, nonhuman primates, and humans]
18. Barthold SW. Global challenges in diagnosing and managing Lyme disease—closing knowledge gaps. Testimony before House
Committee on Foreign Affairs, United States Congress, 17 July 2012.
19. Battafarano DF, Combs JA, Enzenauer RJ, Fitzpatrick JE (1993) Chronic septic arthritis caused by Borrelia burgdorferi. Clin Orthop
297: 238-241. doi: 10.1097/00003086-199312000-00038. [Patients with chronic septic Lyme arthritis of the knee for seven years,
despite multiple antibiotic trials and synovectomies. Bb documented in synovium and synovial fluid.]
20. Baum E, Hue F, Barbour AG (2012) Experimental infections of the reservoir species Peromyscus leuopus with diverse strains of
Borrelia burgdorferi, a Lyme disease agent. MBio 3: e00434-12. doi: 10: 10.1128/mbio.00434-12.
21. Bayer ME, Zhang L, Bayer MH. Borrelia burgdorferi DNA in the urine of treated patients with chronic Lyme disease symptoms. A
PCR study of 97 cases. Infection 1996; 24: 347-353. [97 patients who had been treated with antibiotics for extended periods of time
and had symptoms of chronic Lyme were PCR-positive.]
22. de Leeuw BHCGM, Maraha B, Hollemans L, Sprong H, Brandenburg AH, Westenend PJ, Kusters JG. Evaluation of Borrelia real
time PCR DNA targeting OspA, FlaB and 5S-23S IGS and Borrelia 16S rRNA-qPCR. Journal of Microbiological Methods (2014).
http://doi.org/10.1016/j.mimet.2014.09.001.
23. Benjamin J and J Luft. Chronic Lyme disease; an evolving syndrome. 9th Annual International Scientific Conference on Lyme Disease
& Other Tick-Borne Disorders. 1996.
24. Berglund J, Stjernberg L, Ornstein K, Tykesson-Joelsson K, Walter H. 5-y follow-up study of patients with neuroborreliosis. Scand. J.
Infect. Dis. 2002; 34(6): 421-425.
25. Berndtson K. Review of evidence for immune evasion and persistent infection in Lyme disease. Int J of General Medicine 2013; 6:
291-306. [Lyme disease spirochetes are adapted to persist in immune competent hosts; they are can remain infective despite
aggressive antibiotic challenge.]
26. Bloom BJ, Wyckoff PM, Meissner HC, and Steere AC. Neurocognitive abnormalities in children after classic manifestations of Lyme
disease. Pediatric Infect. Dis. J. 1998; 17(3): 189-196.
27. Bradley JF, Johnson RC, Goodman JL (1994) The persistence of spirochetal nucleic acids in active Lyme arthritis. Ann Intern Med
120: 487-489. doi: 10.7326/0003-4819-120-6-199403150-00007 [human]
28. Bransfield R, Brand S, and Sherr V. Treatment of patients with persistent symptoms and a history of Lyme disease. N Engl Med 2001;
345: 1424-5.
29. Breier F, Khanakah G, Stanek G, Aberer E, Schmidt B, and Tappeiner G. Isolation and polymerase chain reaction typing of Borrelia
afzelii from a skin lesion in a seronegative patient with generalized ulcerating bullous lichen sclerosus et atrophicus. Br J Dermatol
2001; 144: 387-392.
30. Bockenstedt LK, J Mao, E Hodzic, SW Barthold, and D Fish. Detection of attenuated, non-infectious spirochetes in Borrelia
burgdorferi-infected mice after antibiotic treatment. J Infect Dis 2002; 186: 1430-1437. [in mice]
31. Bockenstedt LK, Gonzalez DG, Hamberman AM, Belperron A (2012) Spirochete antigens persist near cartilage after murine Lyme
borreliosis therapy. J Clin Invest 122: 2652-2660. doi: 10.1172/jci58813.
32. Breier F, Kkhkanakah G, Stanek G, Kunz G, Aberer E, Schmidt B, and Tappeiner G. Isolation and polymerase chain reaction of
Borrelia afzelii from a skin lesion in a seronegative patient with generalized ulcereating bullous lichen sclerosus et atrophicus. Br J
Dermatol 2001; 144: 387-392.
33. Brorson O and Brorson S-H. Transformation of cystic forms of Borrelia burgdorferi to normal mobile spirochetes. Infection. 1997;
25: 240-246. [change in physical characteristics; change of spirochetes to other pleomorphic forms, i.e., cell wall deficient forms,
namely cysts.]
34. Brorson O and Brorson S. In vitro conversion of Borrelia burgdorferi to cystic forms in spinal fluid, and transformation to mobile
spirochetes by incubation in BSK-H medium. Infection. 1998; 26: 144-150. [change in physical characteristics; change of spirochetes
to other pleomorphic forms, i.e., cell wall deficient forms, namely cysts.]
35. Brorson O and Brorson SH. An in vitro study of the susceptibility of mobile and cystic forms of Borrelia burgdorferi to
metronidazole. APMIS 1999; 107: 566-576.
36. Brorson O and Brorson SH. An in vitro study of the susceptibility of mobile and cystic forms of Borrelia burgdorferi to tinidazole.
International Microbiol 2004; 7: 139-142.
37. Brorson O and Brorson SH. An in vitro study of the activity of telithromycin against mobile and cystic forms of Borrelia afzelii.
Infection 2006; 34: 26-28.
38. Brorson O Brorson SH, Scythes J, MacAllister J, Wier A, and Margulis L. Destruction of spirochete Borrelia burgdorferi round-body
propag ules (RBs) by the antibiotic tigecycline. Proc Natl Acad Sci USA 2009; 106: 18656-61
39. Brown JP, Zachary JF, Teuscher C, Weis JJ, and Wooten M. Dual role of interleukin-10 in murine Lyme disease: regulation of
arthritis severity and host defense. Infect Immun 1999; 67: 5142-5150. [suppression of harmful immune responses: defense stratagem
of B. burgdorferi]
40. Burrascano J. Failure of aggressive antibiotic therapy to protect the placenta from invasion by B. burgdorferi in a pregnant patient
with Lyme borreliosis. 6th Annual International Science Conference on Lyme Disease and other Tick-borne Diseases.1993.
41. Cabello FC, Godfrey HP, and Newman SA. Hidden in plain sight: Borrelia burgdorferi and the extracellular matrix. Trends in
Microbiology 2007; 15: 350-354. [sequestration]
42. Cadavid D, O’Neill T, Schaefer H, and Pachner AR. Localization of Borrelia burgdorferi in the nervous system and organs in a
nonhuman primate model of Lyme disease. Lab Invest 2000; 80: 1043-1054.
43. Cadavid D, Y Bai, E Hodzic, K Narayan, SW Barthold, and Pachner AR. Cardiac involvement in non-human primates infected with
the Lyme disease spirochete Borrelia burgdorferi. Lab Invest 2004; 84: 1439-1450. [in monkeys]
44. Cameron D, Gaito A, Harris N et al. Evidence-based guidelines for the management of Lyme disease. Expert Rev Anti-Infect. Ther
2004; 2 (Suppl. 1), S1-S13.
45. Cameron D. Results from Lyme disease treatment trial. Columbia University/LDA Conference, Lyme & Other Tick-Borne Diseases:
Emerging Tick-Borne Diseases. October 28, 2005; Philadelphia, Pennsylvania.
46. Cameron DJ. Generalizability in two clinic trials of Lyme disease. Perspectives and Innovation 2006; 3(12).
[http://dx.doi.org/10.1186/1742-5573-3-12].
47. Cameron D. Severity of Lyme disease with persistent symptoms. Insights from a double-blind placebo-controlled clinical trial.
Minerva Med 2008; 99: 489-496.
48. Cameron DJ. Insufficient evidence to deny antibiotic treatment to chronic Lyme disease patients. Med Hypotheses (2009),
doi:10.1016i/j.mehy.2009.01.017
49. Cameron DJ. Proof that Lyme disease exists. 2010. [http://www.hindawi.com/60587146.html].
50. Cameron DJ. Proof that chronic Lyme disease exists. Interdisciplinary Perspect Infect Dis 2010. doi:10.1155/2010/876450.
51. Chancellor MB, McGinnis DE, Shenot PJ, Kiilholma P, and Hirsch IH. Urinary dysfunction in Lyme disease. J Urol 1993; 149: 26-30.
52. Chang YK, Ku YW, Chang CF, Chang CD, McDonough SP, Divers T, Pough M, and Torres A. Antibiotic treatment of
experimentally Borrelia burgdorferi-infected ponies. Vet Microbiol 2005; 107: 285-294.
53. Chao L-L, Lu C-F, and Shih C-M. Molecular detection and genetic identification of Borrelia garinii and Borrelia afzelii from patients
presenting with a rare skin manifestation of prurigo pigmentosa in Taiwan. Int J Infect Dis 2013,
http://dx.doi.org/10.1016/j.ijid.2013.08.004.
54. Chary-Valckenaere I, Jaulhac B, Champigneulle J, Piement Y, Mainard D, and Pourel J. Ultrastructural demonstration of intracellular
localization of Borrelia burgdorferi in Lyme arthritis. Br J Rheumatol 1998; 37: 468-470.
55. Chmielewski T, Tylewlska-Wierzhanowska S. Inhibition of fibroblast apoptosis by Borrelia afzelii, Coxiella burnetii and Bartonella
henselae. Poll Microbiol 2011; 60(3); 269-272.
56. Cimmino MA, Azzolini A, Tobia F, Pesce CM. Spirochetes in the spleen of a patient with chronic Lyme disease. Am J Clin Pathol
1989; 91(1): 95-97.
57. Clarke AE, Esdaile JM, Bloch DA, Lacaille D, Danoff, and Fries JF. A Canadian study of the total medical costs for patients with
systemic lupus erythema and the predictors of costs. Arthrit. Rheum. 1993; 36(11): 1548-1593.
58. Cleveland CP, Dennler PS, Duray PH. Recurrence of Lyme disease presenting as a chest wall mass: Borrelia burgdorferi was
present despite five months of IV ceftriaxone 2 g, and three months of oral cefixime 400 mg BID. The presence of Borrelia
burgdorferi confirmed by biopsy and culture. Poster presentation at V Lyme Disease Foundation International Scientific Conference.
Stamford, CT, April 10-11, 1992.
59. Cleveland CP, and Dennler S. Case history: recurrence of Lyme disease as a chest wall mass. Abstract presented at the 1993 LDF
International Conference on Lyme Disease.
60. Coyle P. Lyme Disease. Mosby Year Book, pp. 235, 1993. St Louis, Mo. [seclusion into immune privileged sites: defense strategies of
B. burgdorferi]
61. Craft J, Fischer DK, Shimamoto GT, Steere AC. Antigens of Borrelia burgdorferi recognized during Lyme disease appearance of a
new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness. J. Clin. Invest. 1986; 1978:
934-939.
62. Dattwyler RJ, Volkman DJ, Luft BJ, Halperin JJ, Thomas J, and Golightly MG. Seronegative Lyme disease. Dissociation of specific
T- and B-lymphocyte response to Borrelia burgdorferi. N Engl J Med 1988; 319(22): 1441-1446.
63. Dejmková H, D Hulinska, D Tegzová, K Pavelka, J Gatterová, and P Vavřik. Seronegative Lyme arthritis caused by Borrelia garinii.
Clin Rheumatol 2002; 21:330-334.
64. DeLong AK, Blossom B, Maloney E, and Phillips SE. Antibiotic retreatment of Lyme disease in patients with persistent symptoms: A
biostatistical review of randomized, placebo-controlled, clinical trials. Contemp Clin Trials 2012; epub ahead of print.
http://dx.doi.org/10.1016/j.cct.2012.08.009. [refutes Klempers {2001} conjecture that long-term antibiotics don’t work]
65. de Koning J, et al. Demonstration of spirochetes in cardiac biopsies of patients with Lyme disease. J. Infect. Dis. 1989; 160: 150-153.
[intracellular sanctuaries of Bb]
66. Demaershalck I, Messaoud AB, de Kesel M, Hoyois B, Lobet Y, Hoet P, Bigaignon G, Bollen A, and Godfroid E. Simultaneous
presence of different Borrelia burgdorferi genospecies in biological fluids of Lyme disease patients. J Clin Microbiol 1995: 33; 602-
608.
67. Diterich I, Rauter C, Kirschning CJ, and Hartung T. Borrelia burgdorferi-induced tolerance as a model of persistence via
immunosuppression. Infect Immun 2003; 71(7):3979-3987.
68. Donahue JG, Piesman J, Spielman A (1987) Reservoir competence of white-footed mice for Lyme disease spirochetes. Am J Trop
Med Hyg 36: 92-96. [persistence in white-footed mice]
69. Donta ST. Tetracycline therapy for chronic Lyme disease. Clin Inf Dis 1997; 25 (Suppl 1); S52-56.
70. Donta ST. The existence of chronic Lyme disease. Curr Treat Op Infect Dis 2001; 3: 261-262.
71. Donta ST. Late and chronic Lyme disease. Med Clin North Am 2002; 86: 341-349.
72. Donta ST. Macrolide therapy of chronic Lyme disease. Med Sci Monit 2003; 9: 136-142.
73. Dorward DW, Fischer ER, and Brooks DM. Invasion and cytopathic killing of human lymphocytes by spirochetes causing Lyme
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This section compiled by: John D. Scott, Research Division, Lyme Ontario, February 2015
Psychiatric Symptoms and Lyme/Tick-Borne Diseases
This section is organized alphabetically by the title of the article.
A controlled study of deficits in children with chronic Lyme disease. AUTHORS: Tager, F., Fallon, B., Keilp, J, Rissenberg, M., Jones, C.R. &
Liebowitz, M. SOURCE: Journal of Neuropsychiatry and Clinical Neurosciences, 2001; 13: 500-507.
Acute disseminated encephalomyelitis [letter] AUTHORS: Fallon BA, Nields JA. SOURCE: J Neuropsychiatry Clin Neurosci 1998
Summer;10(3):366-7
Acute and Chronic Lyme Disease: Controversies for Neuropsychiatry AUTHORS: Hurley RA, Taber KH. SOURCE: J Neuropsychiatry Clin
Neurosci 20:1, Winter 2008 http://neuro.psychiatryonline.org
Acute and chronic pain associated with Lyme borreliosis: clinical characteristics and pathophysiologic mechanisms. AUTHORS: Zimering JH,
Williams MR, Eiras ME, Fallon BA, Logigian EL, Dworkin RH et al. SOURCE: Pain. 2014 Aug;155(8):1435-1438.
Acute and chronic neuroborreliosis with and without CNS involvement: a clinical, MRI, and HLA study of 27 cases. AUTHORS: Krüger H,
Heim E, Schuknecht B, Scholz S. SOURCE: J Neurol. 1991 Aug;238(5):271-80.
Acute Lyme Neuroborreliosis With Transient Hemiparesis and Aphasia AUTHORS: Sokolov A, Lienhard R, Du Pasquier R, Véronique Erard V
SOURCE: Annals of Emergency Medicine. Published Online: February 25, 2015 http://www.annemergmed.com/article/S0196-
0644(15)00028-1/abstract
A Girl with Seizures AUTHOR: Carla Rothaus SOURCE: NEJM. May 22nd, 2015
http://blogs.nejm.org/now/index.php/a-girl-with-seizures/2015/05/22/comment-page-1/#comment-225701 A Groundhog, a Novel Bartonella
Sequence, and My Father’s Death AUTHORS: Breitschwerdt EB, Maggi RG, Cadenas MB, Vissotto de Paiva Diniz PP SOURCE: Emerging
Infectious Diseases • www.cdc.gov/eid • 2009 Aug;15(12): 2080-6 http://www.cdc.gov/eid/content/15/12/pdfs/2080.pdf
Alcohol and epilepsy: A case report between alcohol withdrawal seizures and neuroborreliosis. AUTHORS: Gheorghiev C, De Montleau F,
Defuentes G SOURCE: Encephale 2011 06; 37 (3): 231-237
[Alcohol and epilepsy: a case report between alcohol withdrawal seizures and neuroborreliosis]. AUTHORS: Gheorghiev C, De Montleau F,
Defuentes G. SOURCE: Encephale. 2011 Jun;37(3):231-7.
Altered mental status, an unusual manifestation of early disseminated Lyme disease: A case report. AUTHORS: Chabria SB, Lawrason J.
SOURCE: J Med Case Reports. 2007 Aug 9;1:62.
Alzheimer's disease and infection: Do infectious agents contribute to progression of Alzheimer's disease? AUTHORS: Honjo K, van Reekum R,
Rand Nicolaas, Verhoeff NPLG. SOURCE: Alzheimer's and Dementia. Vol 5;4, July 2009, p 348-360
Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria. AUTHOR: Miklossy J. SOURCE:J
Neuroinflammation. 2011 Aug 4;8(1):90. [Epub ahead of print]
Alzheimer's disease Braak Stage progressions: reexamined and redefined as Borrelia infection transmission through neural circuits. AUTHOR:
MacDonald AB. SOURCE: Med Hypotheses. 2007;68(5):1059-64. Epub 2006 Nov 17.
Alzheimer's neuroborreliosis with trans-synaptic spread of infection and neurofibrillary tangles derived from intraneuronal spirochetes.
AUTHOR: MacDonald AB. SOURCE: Med Hypotheses. 2007;68(4):822-5. Epub 2006 Oct 20.
Antibodies against OspA epitopes of Borrelia burgdorferi cross-react with neural tissue. AUTHORS: Alaedini A, Latov N. SOURCE: J
Neuroimmunol. 2005 Feb;159(1-2):192-5. Epub 2004 Nov 26.
Anti-neural antibody reactivity in patients with a history of Lyme borreliosis and persistent symptoms. AUTHORS: Stricker RB, Johnson L
SOURCE: Brain, Behavior, and Immunity 24 (2010) 1025
Anti-neural antibody reactivity in patients with a history of Lyme borreliosis and persistent symptoms. AUTHORS: Volkman D SOURCE:
Brain, Behavior, and Immunity 24 (2010) A Review of Death Certificates Listing Lyme Disease as a Cause of Death in the United States.
AUTHORS: Kugeler KJ, Griffith KS, Gould LH et al. SOURCE: Clin Infect Dis. (2011) 52 (3), 364-367. doi: 10.1093/cid/ciq157
http://cid.oxfordjournals.org/content/52/3/364.full.pdf http://cid.oxfordjournals.org/content/52/3/364.long
The association between tick-borne infections, Lyme borreliosis and autism spectrum disorders AUTHORS: Bransfield RC, Wulfman JS,
Harvey WT, Usman AI. SOURCE: Medical Hypotheses. 5 Nov 2007
Association of Lyme Disease and Schizoaffective Disorder, Bipolar Type: Is it Inflammation Mediated? AUTHORS: Mattingley DW, Koola
MM. SOURCE: Indian J Psychol Med. 2015 Apr-Jun;37(2):243-6.
Audiologic manifestations of patients with post-treatment Lyme disease syndrome AUTHORS: Shotland LI, Mastrioanni MA, Choo DL,
Szymko-Bennett YM, Dally LG, Pikus AT, Sledjeski K, Marques A SOURCE: Ear Hear. 2003 Dec;24(6):508-17
Autism and Lyme Disease AUTHORS: Robert C. Bransfield, MD, Mason Kuhn, MS. SOURCE: JAMA. 2013;310(8):856
doi:10.1001/jama.2013.194747
A woman in her 50s with manic psychosis. AUTHORS: Pasareanu AR, Mygland Å, Kristensen Ø. SOURCE: Tidsskr Nor Laegeforen. 2012
Mar 6;132(5):537-9
Bartonella henselae bacteremia in a mother and son potentially associated with tick exposure AUTHORS: Maggi RG, Ericson M,
Mascarelli PE, Bradley JM, Breitschwerdt EB SOURCE: Parasites & Vectors April 2013, 6:101 doi:10.1186/1756-3305-6-101
http://dx.doi.org/10.1186/1756-3305-6-101
Bartonella henselae infection in a family experiencing neurological and neurocognitive abnormalities after woodlouse hunter spider bites
AUTHORS: Mascarelli PE, Maggi RG, Hopkins S, Mozayeni BR, Trull CL, Bradley JM, Hegarty BC, Breitschwerdt EB SOURCE: Parasites
& Vectors 2013, 6:98 doi:10.1186/1756-3305-6-98 http://www.parasitesandvectors.com/content/6/1/98/abstract
Bartonella sp. Bacteremia in Patients with Neurological and Neurocognitive Dysfunction. AUTHORS: Journal of Clinical Midrobiology.
46(9):2856–2861 SOURCE: Breitschwerdt EB. Maggi RG, Nicholson WL, Cherry NA, Woods CW.
The basic syndromes of neurological disorders in Lyme borreliosis: AUTHORS: Dekonenko EP, Umanskii KG, Virich IE, Kupriianova LV,
Rudometov, IuP, Bagrov FI: SOURCE: Ter Arkh 1995; 67 (11) : 52-53
Benefit of intravenous antibiotic therapy in patients referred for treatment of neurologic Lyme disease. AUTHORS: Stricker RB, Delong AK,
Green CL, Savely VR, Chamallas SN, Johnson L SOURCE: Int J Gen Med 2011 9; 4 : 639-646
Behavioral Consequences of Infections of the Central Nervous System: With Emphasis on Viral Infections. AUTHORS: Tselis A, MD, Booss J.
SOURCE: J Am Acad Psychiatry Law 31:289–98, 2003
Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes. AUTHORS: Miklossy J, Kis A, Radenovic A, Miller L,
Forro L, Martins R, Reiss K, Darbinian N, Darekar P, Mihaly L, Khalili K. SOURCE: Neurobiol Aging. 2006 Feb;27(2):228-36.
Bell’s Palsy of the Gut and other Manifestations of Lyme and Associated Diseases. AUTHOR: Sherr VT SOURCE: Practical Gastroenterology
April 2006
Benefit of intravenous antibiotic therapy in patients referred for treatment of neurologic Lyme disease. AUTHORS: Stricker RB, DeLong AK,
Green C, Savely VR, Chamallas SN, Johnson L. SOURCE: International Journal of General Medicine 2011:4 639–646
http://www.dovepress.com/articles.php?article_id=8224.
Bilateral dorsolateral thalamic lesions disrupts conscious recollection. AUTHORS: Edelstyn NM, Hunter B, Ellis SJ. SOURCE:
Neuropsychologia. 2006;44(6):931-8. Epub 2005 Oct 25.
Biology and neuropathology of dementia in syphilis and Lyme disease. AUTHOR: MIKLOSSY J EDITORS: Duyckaerts C, Litvan I
SOURCE: Handbook of Clinical Neurology, Vol. 89 (3rd series) Dementias 2008 Elsevier B.V.
http://www.miklossy.ch/media/ChapterHandbookClinNeurolFinalPdf.pdf
Borrelia Burgdorferi: A Clinical Chameleon AUTHORS: Samuel B, Axelband J, Mckim K, Leh D. SOURCE: Consultant. 2015;55(7):530-535.
http://www.consultant360.com/articles/borrelia-burgdorferi-clinical-chameleon
Borrelia burgdorferi: Cell Biology and Clinical Manifestations in Latent Chronic Lyme. AUTHORS: Smith AJ, Oertle J, Prato D SOURCE:
Open Journal of Medical Microbiology, Vol.4 No.4, December 2014
http://www.scirp.org/Journal/PaperInformation.aspx?PaperID=51411#.VJDlHivF9M1
Borrelia burgdorferi in the central nervous system: experimental and clinical evidence for early invasion. AUTHORS: Garcia-Monco JC, Villar
BF, Alen JC, Benach JL. SOURCE: J Infect Dis. 1990 Jun;161(6):1187-93.
Borrelia burgdorferi central nervous system infection presenting as an organic schizophrenialike disorder. AUTHORS: Hess A, Buchmann J,
Zettl UK, Henschel S, Schlaefke D, Grau G, Benecke R. SOURCE: Biol Psychiatry 1999 Mar 15;45(6):795
Borrelia burgdorferi in the nervous system: the new "great imitator". AUTHOR: Pachner AR. SOURCE: Ann N Y Acad Sci. 1988;539:56-64.
Borrelia burgdorferi persists in the brain in chronic lyme neuroborreliosis and may be associated with Alzheimer disease. AUTHORS: Miklossy
J, Khalili K, Gern L, Ericson RL, Darekar P, Bolle L, Hurlimann J, Paster BJ. SOURCE: J Alzheimers Dis. 2004 Dec;6(6):639-49; discussion
673-81.
Borrelia burgdorferi-seropositive chronic encephalomyelopathy: Lyme neuroborreliosis? An autopsied report. AUTHORS: Kobayashi K,
Mizukoshi C, Aoki T, Muramori F, Hayashi M, Miyazu K, Koshino Y, Ohta M, Nakanishi I, Yamaguchi N. SOURCE: Dement Geriatr Cogn
Disord. 1997 Nov-Dec;8(6):384-90.
[Borreliosis--simultaneous Lyme carditis and psychiatric disorders--case report] AUTHORS: Legatowicz-Koprowska M, Gziut AI, Walczak E,
Gil RJ, Wagner T. SOURCE: Pol Merkur Lekarski. 2008 May;24(143):433-5. Polish.
Brain SPECT Imaging in Chronic Lyme Disease. AUTHORS: Plutchok JJ, Tikofsky RS, Liegner KB, Fallon BA, Van Heertum RL. SOURCE:
Journal of Spirochetal and Tick Borne-Diseases, 1999; 6: 10-16.
Can infections and immune reactions to them cause violent behavior? AUTHOR: Bransfield RC SOURCE: Abstracts of 11th
Psychoimmunology Expert Meeting, March 8–11, 2012
Neurology, Psychiatry and Brain Research. Volume 18, Issue 2, Page 42 (March 2012)
Carbamazepine in the treatment of Lyme disease-induced hyperacusis. AUTHORS: Nields JA, Fallon BA, Jastreboff PJ. SOURCE: J
Neuropsychiatry Clin Neurosci 1999 Winter;11(1):97-9
A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe. AUTHORS: Hovius JWR et al. SOURCE:
www.thelancet.com Vol 382 August 17, 2013
Case report: Lyme disease and complex partial seizures. AUTHOR: Bransfield RC. SOURCE: Journal of Spirochetes and Tick-borne Diseases;
Fall/Winter 1999, Vol 6, p123-125
Case Shows How Lyme Disease Can Mimic New-Onset Panic Disorder. AUTHOR: Sinclair L SOURCE: Psychiatric News. 2013 Vol 48(13)1
DOI: 10.1176/appi.pn.2013.6b19 http://psychnews.psychiatryonline.org/newsarticle.aspx?articleid=1700960
Catatonia in a 14 year-old girl: treatment with clorazepam and carbamazepine, a 10-year follow-up]. AUTHORS: Askenazy F, Dor E, Benoit M,
Dupuis G, Serret S, Myquel M, Seddiki Y. SOURCE: Encephale. 2010 Feb;36(1):46-53.
Catatonic syndrome in acute severe encephalitis due to Borrelia burgdorferi infection.
Pfister HW, Preac-Mursic V, Wilske B, Rieder G, Forderreuther S, Schmidt S, AUTHORS: Kapfhammer HP. SOURCE: Neurology. 1993
Feb;43(2):433-5.
Central nervous system manifestations of human ehrlichiosis. AUTHORS: Ratnasamy N, Everett ED, Roland WE, McDonald G, Caldwell CW.
SOURCE: Clin Infect Dis 1996 Aug;23(2):314-9
Central nervous system manifestations of Lyme disease. AUTHORS: Pachner AR, Duray P, Steere AC. SOURCE: Arch Neurol. 1989
Jul;46(7):790-5.
Cerebral metabolic changes associated with Lyme disease AUTHORS: Newberg A, Hassan A, Alavi A. SOURCE: Nucl Med Commun 2002
August;23(8):773-777
Chronic Bacterial and Viral Infections in Neurodegenerative and Neurobehavioral Diseases. AUTHORS: Nicholson GL. SOURCE: Lab
Medicine. 2008;39(5):291-9.
Chronic borrelia encephalomyeloradiculitis with severe mental disturbance: immunosuppressive versus antibiotic therapy. AUTHORS:
Kollikowski HH, Schwendemann G, Schulz M, Wilhelm H, Lehmann HJ. SOURCE: J Neurol. 1988 Jan;235(3):140-2.
Chronic central nervous system involvement in Lyme borreliosis. AUTHORS: Kohler J, Kern U, Kasper J, Rhese-Küpper B, Thoden U.
SOURCE: Neurology. 1988 Jun;38(6):863-7.
Chronic inflammation and amyloidogenesis in Alzheimer's disease -- role of Spirochetes. AUTHORS: Miklossy J. SOURCE: J Alzheimers Dis.
2008 May;13(4):381-91. Review.
Chronic Lyme Disease Linked to ADHD in Adults. AUTHOR: Young JL SOURCE: American Psychiatric Association's 2012 Annual Meeting.
Medscape. May 08,2012. http://www.medscape.com/viewarticle/763458
Chronic neuroborreliosis in infancy. AUTHORS: Zamponi N, Cardinali C, Tavoni MA, Porfiri L, Rossi R, Manca A. SOURCE: Ital J Neurol
Sci (1999) 20:303-307
Chronic neurologic manifestations of erythema migrans borreliosis. AUTHORS: Ackermann R, Rehse-Kupper B, Gollmer E, Schmidt R.
SOURCE: Ann N Y Acad Sci. 1988;539:16-23.
Chronic neurologic manifestations of Lyme disease. AUTHORS: Logigian EL, Kaplan RF, Steere AC. SOURCE: N Engl J Med. 1990 Nov
22;323(21):1438-44.
Chronic or late lyme neuroborreliosis: analysis of evidence compared to chronic or late neurosyphilis. AUTHORS: Miklossy J. SOURCE: Open
Neurol J 2012; 6: 146-57.
Chronic or Late Lyme Neuroborreliosis: Present and Future. AUTHORS: Miklossy J, Donta S, Mueller K, Nolte O, Perry G. SOURCE: The
Open Neurology Journal. 2012; 6: Pp. 78 [DOI: 10.2174/1874205X01206010078]
http://benthamscience.com/open/toneuj/articles/V006/SI0078TONEUJ/78TONEUJ.pdf
Clinical and demographic characteristics of psychiatric patients seropositive for Borrelia burgdorferi. AUTHORS: Hájek T, Libiger J, Janovská
D, Hájek P, Alda M, Höschl C. SOURCE: Eur Psychiatry. 2006 Mar;21(2):118-22.
[Clinical manifestations and epidemiological aspects leading to a diagnosis of Lyme borreliosis: neurological and psychiatric manifestations in
the course of Lyme borreliosis] AUTHORS: Créange A. SOURCE: Med Mal Infect. 2007 Jul-Aug;37(7-8):532-9. Epub 2007 Mar 26. Review.
French.
Co-existance of toxoplasmosis and neuroborreliosis - a case report. AUTHORS: Gustaw K, Beltowska K, Dlugosz E. SOURCE: Ann Agric
Environ Med. 2005;12(2):305-8.
Coexisting of borreliosis, depression and psoriasis--case report. AUTHORS: Oglodek E, Mos D, Araszkiewicz A. SOURCE: Pol Merkur
Lekarski. 2010 Jan;28(163):53-5.
Cognitive functioning in late Lyme borreliosis. AUTHORS: Krupp LB, Masur D, Schwartz J, Coyle PK, Langenbach LJ, Fernquist SK, Jandorf
L, Halperin JJ. SOURCE: Arch Neurol. 1991 Nov;48(11):1125-9.
Cognitive Impairments after Tick-borne Encephalitis. AUTHORS: Gustaw-Rothenberg K. SOURCE: Dementia and Geriatric Cognitive
Disorders. 2008;26:165-168.
Cognitive processing speed in Lyme disease. AUTHORS: Pollina DA, Sliwinski M, Squires NK, Krupp LB. SOURCE: Neuropsychiatry
Neuropsychol Behav Neurol. 1999 Jan;12(1):72-8.
Complaints attributed to chronic Lyme disease: depression or fibromyalgia? AUTHORS: Berman DS, Wenglin BD. SOURCE: Am J Med. 1995
Oct;99(4):440.
Concepts of trust among patients with serious illness. AUTHORS: Mechanic D, Meyer S. SOURCE: Soc Sci Med. 2000 Sep;51(5):657-68.
Concurrent infection of the central nervous system by Borrelia burgdorferi and Bartonella henselae: evidence for a novel tick-borne disease
complex. AUTHORS: Eskow E, Rao RV, Mordechai E. SOURCE: Arch Neurol. 2001 Sep;58(9):1357-63.
Concurrent Lyme disease and babesiosis. Evidence for increased severity and duration of illness. AUTHORS: Krause PJ, Telford SR 3rd,
Spielman A, Sikand V, Ryan R, Christianson D, Burke G, Brassard P, Pollack R, Peck J, Persing DH. SOURCE: JAMA. 1996 Jun
5;275(21):1657-60.
Concurrent medical conditions with pediatric bipolar disorder. AUTHORS: Scheffer RE, Linden S SOURCE: Curr Opin Psychiatry. (2007)
20(4), 398-401. Review.
Concurrent neocortical borreliosis and Alzheimer's disease: Demonstration of a spirochetal cyst form. AUTHOR: MacDonald AB. SOURCE:
Ann N Y Acad Sci 1988; 539:468-470.
Concurrent medical conditions with pediatric bipolar disorder. AUTHORS: Scheffer RE, Linden S. SOURCE: Curr Opin Psychiatry. 2007
Jul;20(4):398-401. Review.
Consequences of treatment delay in Lyme disease. AUTHORS: Cameron DJ SOURCE: J Eval Clin Pract. 2007 Jun;13(3):470-2.
Constipation Heralding Neuroborreliosis AUTHORS: Shamim A, Shamim S; Liss G; Nylen E; Pincus J; Yepes M. SOURCE: Arch Neurol.
2005;62:671-673.
A Controlled Study of Cognitive Deficits in Children With Chronic Lyme Disease AUTHORS: Tager FA, Fallon BA, Keilp J, Rissenberg M,
Jones CR, Liebowitz MR. SOURCE: J Neuropsychiatry Clin Neurosci 13:500-507, November 2001
FULL TEXT: http://www.lymediseaseassociation.org/Tager.pdf
Correlates of Perceived Health-Related Quality of Life in Post-treatment Lyme Encephalopathy. Authors: Chandra AM, Keilp JG, Fallon BA
Source: Psychosomatics 2013(Jul)
Psychosomatics. 2013 Jul 9. pii: S0033-3182(13)00078-9. doi:10.1016/j.psym.2013.04.003. [Epub ahead of print]
Delirium and Lyme disease. AUTHORS: Caliendo MV, Kushon DJ, Helz JW. SOURCE: Psychosomatics. 1995 Jan-Feb;36(1):69-74.
Delusional disorders in the course of tick-born encephalitis and borreliosis in patients with hemophilia A and posttraumatic epilepsy--diagnostic
and therapeutic difficulties] AUTHORS: Grzywa A, Karakuła H, Górecka J, Chuchra M. SOURCE: Pol Merkur Lekarski. 2004 Jan;16(91):60-
3. Polish.
Dementia associated with infectious diseases. AUTHOR: Almeida OP, Lautenschlager NT. SOURCE: Int Psychogeriatr. 2005;17 Suppl 1:S65-
77. Review.
Demyelinating polyradiculitis in neuro borreliosis: AUTHORS: Corral I, Sanchis G, Garcia-Ribas G, Quereda C, Escudero R, de Blas G:
SOURCE: Neurologia 1995 Feb; 10 (2) : 110-113
Detection of Bartonella henselae by polymerase chain reaction in brain tissue of an immunocompromised patient with multiple enhancing lesions.
Case report and review of the literature. AUTHORS: George TI, Manley G, Koehler JE, Hung VS, McDermott M, Bollen A. SOURCE: J
Neurosurg. 1998 Oct;89(4):640-4. Review.
Diagnosis of Infectious or Inflammatory Psychosyndromes. AUTHOR: Bechter K. SOURCE: The Open Neurology Journal, 2012, 6:113-118.
[DOI: 10.2174/1874205X01206010113] http://benthamscience.com/open/toneuj/articles/V006/SI0078TONEUJ/113TONEUJ.pdf
The diagnosis of Lyme disease. AUTHOR: Bransfield RC. SOURCE: Hosp Pract (Minneap). 1996 Aug 15;31(8):35, 40.
Diagnosis, treatment, and prevention of Lyme disease. AUTHOR: Bransfield RC. SOURCE: JAMA. 1998 Sep 23-30;280(12):1049; author
reply 1051.
Differential Diagnosis and Treatment of Lyme Disease with Special Reference to Psychiatric Practice. AUTHORS: Nields JA, Fallon BA.
SOURCE: Directions in Psychiatry, 1998, 18: 209-228.
Differential Diagnosis and the Suspension of Judgment. AUTHOR: Ashley Graham Kennedy* SOURCE: J Med Philos (2013) doi:
10.1093/jmp/jht043 First published online: August 29, 2013 http://jmp.oxfordjournals.org/content/early/2013/08/28/jmp.jht043
[Differential diagnostic problems in Lyme disease (Borrelia infection resulting in acute exogenous psychosis)] AUTHORS: Császár T,
Patakfalvi A. SOURCE: Orv Hetil. 1994 Oct 9;135(41):2269-71.
A disease in disguise. Lyme can masquerade as migraine, or as madness. AUTHORS: Cowley G, Underwood A. SOURCE: Newsweek. 2004
Aug 23;144(8):62.
Divergent Opinions of Proper Lyme Disease Diagnosis and Implications For Children Co-Morbid with Autism Spectrum Disorder. AUTHORS:
Kuhn M, Bransfield RC. SOURCE: Medical Hypotheses Accepted: June 6, 2014; Published Online: June 16, 2014. http://www.medicalhypotheses.com/article/S0306-9877(14)00233-3/abstract
Do bartonella infections cause agitation, panic disorder, and treatment-resistant depression? AUTHORS: Schaller JL, Burkland GA, Langhoff
PJ. SOURCE: MedGenMed. 2007 Sep 13;9(3):54.
Does process-specific slowing account for cognitive deficits in Lyme disease? AUTHORS: Pollina DA, Elkins LE, Squires NK, Scheffer SR,
Krupp LB. SOURCE: Appl Neuropsychol. 1999;6(1):27-32.
Early disseminated Lyme disease: Lyme meningitis. AUTHOR: Pachner AR SOURCE: Am J Med; (1995) 98(4A):30S-37S
Early-life programming of later-life brain and behavior: a critical role for the immune system. AUTHORS: Staci D. BilboSD, Jaclyn M. Schwarz
JM. SOURCE: Frontiers in Behvrioral Neurosciences. 2009:3
Efficacy of a long-term antibiotic treatment in patients with a chronic Tick Associated Poly-organic Syndrome (TAPOS). AUTHOR: Clarissou J,
Song A, Bernede C, Guillemot D, Dinh A, Ader F, Perronne C, Salomon J. SOURCE: Med Mal Infect. 2009 Feb;39(2):108-15. Epub 2009 Jan
4.
Elevated cerebrospinal fluid kynurenic acid levels in patients with tick-borne encephalitis. AUTHORS: Holtze M, Mickiene´ A. Atlas A,
Lindquist L, Schwieler L. SOURCE: Journal of Internal Medicine. 2012, 272; 394–401.
Emerging infectious determinants of chronic diseases. AUTHORS: O'Connor SM, Taylor CE, Hughes JM. SOURCE: Emerg Infect Dis. 2006
Jul;12(7):1051-7.
Endogenous paranoid-hallucinatory syndrome caused by Borrelia encephalitis AUTHORS: Barnett W, Sigmund D, Roelcke U, Mundt C.
SOURCE: Nervenarzt 1991 Jul;62(7):445-7 [German]
Epidemiologic, clinical, and laboratory findings of human ehrlichiosis in the United States, 1988. AUTHORS: Eng TR, Harkess JR, Fishbein
DB, Dawson JE, Greene CN, Redus MA, Satalowich FT. SOURCE: JAMA 1990 Nov 7;264(17):2251-8
Etiopathogenesis of autism spectrum disorders: Fitting the pieces of the puzzle together. AUTHORS: Gentile I, Zappulo E, Militerni R, Pascotto
A, Borgia G, Bravaccio C. SOURCE: Med Hypotheses. 2013 Jul;81(1):26-35. doi: 10.1016/j.mehy.2013.04.002. Epub 2013 Apr 25.
European neuroborreliosis: quality of life 30 months after treatment. AUTHORS: Eikeland R, Mygland A, Herlofson K, Ljøstad U. SOURCE:
Acta Neurol Scand. 2011Nov;124(5):349-54.
[Evaluation of cerebrospinal fluid serotonin (5-HT) concentration in patients with post-Lyme disease syndrome--preliminary study] AUTHORS:
Kepa L, Oczko-Grzesik B, Badura-Glombik T. SOURCE: Przegl Epidemiol. 2008;62(4):793-800. Polish.
Evidence for Mycoplasma, ssp., Chalmydia pneumoniae, and Human Herpes-virus 6 Coinfections in Blood of patients with Autistic Spectrum
Disorders. AUTHORS: Nicholson GL, Gann R, Nicholson NL, Haier J. SOURCE: Journal of Neuroscience Research 2007 85.
Failure of tetracycline therapy in early Lyme disease. AUTHORS: Dattwyler RJ, Halperin JJ. SOURCE: Arthritis Rheum. 1987 Apr;30(4):448-
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AUTHORS: Sherr VT. SOURCE: Practical Gastroenterology, January 2000
Plaques of Alzheimer's disease originate from cysts of Borrelia burgdorferi, the Lyme disease spirochete. AUTHORS: MacDonald AB.
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Polymorphic mental disorders in the course of Lyme borreliosis--case study. AUTHORS: Helon B, Tluczek TW, Buczyjan A, Adamczyk-Helon
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Preventable cases of autism: relationship between chronic infectious disease and neurological outcome. AUTHORS: Bransfield RC. SOURCE:
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Psychologic disorders in acute and persistent neuroborreliosis. AUTHORS: Poplawska R, Konarzewska B, Gudel-Trochimowicz I, Szulc A.
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A randomized, placebo-controlled trial of repeated IV antibiotic therapy for Lyme encephalopathy AUTHORS: Fallon BA, et al. SOURCE:
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Rare and unusual dementias. AUTHORS: Gupta S, Fiertag O, James Warner J. SOURCE: Advances in psychiatric treatment (2009), vol. 15,
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A Reappraisal of the U.S. Clinical Trials of Post-Treatment Lyme Disease Syndrome. AUTHORS: Fallon BA, Petkova E, Keilp JG, Britton CB.
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Recurrent and relapsing course of borreliosis of the nervous system. AUTHORS: Omasits M, Seiser A, Brainin M. SOURCE: Wien Klin
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Regional cerebral blood flow and cognitive deficits in chronic lyme disease. AUTHORS: Fallon BA, Keilp J, Prohovnik I, Heertum RV, Mann
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Regional cerebral blood flow and metabolic rate in persistent Lyme encephalopathy. AUTHORS: Fallon BA, Lipkin RB, Corbera KM, Yu S,
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Relationship of Inflammation and Autoimmunity to Psychiatric Sequelae in Lyme Disease. AUTHOR: Bransfield RC. SOURCE:
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Results of a prospective standardized study of 30 patients with chronic neurological and cognitive disorders after tick bites. AUTHORS: Roche
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"Reversible" dementia in 2011. AUTHORS: Michel JM, Sellal F SOURCE: Geriatr Psychol Neuropsychiatr Vieil 2011 05 1; 9 (2): 211-225
Role of Chronic Bacterial and Viral Infections in Neurodegenerative, Neurobehavioral, Psychiatric, Autoimmune and Fatiguing Illnesses.
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The role of kynurenines in disorders of the central nervous system: Possibilities for neuroprotection. AUTHORS: Vamos E, Pardutz A, Klivenyi
P, Toldi J, Vecsei L. SOURCE: J Neurol Sci. 2009 Mar 4.
Role of psychiatric comorbidity in chronic Lyme disease. AUTHORS: Hassett AL, Radvanski DC, Buyske S, Savage SV, Gara M, Escobar JI,
Sigal LH. SOURCE: Arthritis Rheum. 2008 Dec 15;59(12):1742-9. http://www.ncbi.nlm.nih.gov/pubmed/19035409
Safety of intravenous antibiotic therapy in patients referred for treatment of neurologic Lyme disease. AUTHORS: Stricker RB, Green CL,
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Screening for Lyme disease in hospitalized psychiatric patients: prospective serosurvey in an endemic area. AUTHORS: Nadelman RB, Herman
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Seasonal correlation of sporadic schizophrenia to Ixodes ticks and Lyme borreliosis AUTHOR: Fritzsche M. SOURCE: International Journal
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[Secondary normal pressure hydrocephalus. A complication of chronic neuroborreliosis]. AUTHORS: Druschky K, Stefan H, Grehl H,
Neundörfer B. SOURCE: Nervenarzt. 1999 Jun;70(6):556-9. German.
Severity of Lyme disease with persistent symptoms. Insights from a double-blind placebo-controlled clinical trial. AUTHOR: Cameron D.
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Signs and significance of a tick-bite: psychiatric disorders associated with Lyme disease. AUTHOR: Sno HN. SOURCE: Tijdschr Psychiatr.
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Short-course treatment in neurobrucellosis: a study in Iran. AUTHORS: Asadipooya K, Dehghanian A, Omrani GH, Abbasi F. SOURCE:
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Sleep quality in Lyme disease. AUTHORS: Greenberg HE, Ney G, Scharf SM, Ravdin L, Hilton E. SOURCE: Sleep. 1995 Dec;18(10):912-6.
Spirochetal cyst forms in neurodegenerative disorders,...hiding in plain sight. AUTHORS: MacDonald AB. SOURCE: Med Hypotheses.
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SPECT Brain Imaging in Chronic Lyme Disease. AUTHORS: Donta ST, Noto RB, Vento JA. SOURCE: Clinical Nuclear Medicine & Volume
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Spirochetal diseases of the nervous system. AUTHORS: Cintron R, Pachner AR. SOURCE: Curr Opin Neurol. 1994 Jun;7(3):217-22. Review.
Startle myoclonus induced by Lyme neuroborreliosis: a case report. Authors: Schoof J, Kluge C, Heinze HJ, Galazky I. SOURCE: J Med Case
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Study and treatment of post Lyme disease (STOP-LD): a randomized double masked clinical trial. AUTHORS: Krupp LB, Hyman LG, Grimson
R, Coyle PK, Melville P, Ahnn S, Dattwyler R, Chandler B.SOURCE: Neurology. 2003 Jun 24;60(12):1923-30.
Subarachnoid hemorrhage in a patient with Lyme disease. AUTHORS: Cheherama M, Zagardo MT, Koski CL SOURCE: Neurology
(1997);48:520-523
Successful treatment of Lyme encephalopathy with intravenous ceftriaxone. AUTHORS: Logigian EL, Kaplan RF, Steere AC. SOURCE: J
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Survival strategies of Borrelia burgdorferi, the etiologic agent of Lyme disease. AUTHORS: Embers ME, Ramamoorthy R, Philipp MT.
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Tc-99m HMPAO Brain SPECT Imaging in Chronic Lyme Disease AUTHORS: Plutchok JJ, Tikofsky RS, Liegner K, Kochevar JM, Fallon BA,
Van SOURCE: Heertum RL. J of Spirochetal and Tick-borne Diseases 6: 117-122, 1999.
The association of lyme disease with loss of sexual libido and the role of urinary bladder detrusor dysfunction. AUTHORS: Puri BK, Shah M,
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The lack of correlation between the incidence of Lyme disease and deaths due to Alzheimer’s disease cannot reflect the lack of involvement of
Borrelia burgdorferi in Alzheimer’s dementia AUTHOR: Miklossy J SOURCE: The Journal of Alzheimer’s Disease. Aug 2014 http://jalz.com/node/384
The neuropsychiatric assessment of Lyme disease AUTHOR: Bransfield, R. SOURCE: Available online at www.mentalhealthandillness.com
The neuropsychiatric manifestations of Lyme Borreliosis. AUTHORS: Fallon BA, Nields JA, Burrascano JJ, Liegner K, DelBene D, Liebowitz
MR. SOURCE: Psychiatric Quarterly 1992; 63: 95-117
The American Psychiatric Association Psychiatric Guidelines for the Psychiatric Assessment of Adults Third Edition. AUTHORS: APA Work
Group on Psychiatric Evaluation. SOURCE: http://psychiatryonline.org/doi/pdf/10.1176/appi.books.9780890426760
The Psychoimmunology of Lyme/Tick-Borne Diseases and its Association with Neuropsychiatric Symptoms. AUTHOR: Bransfield RC.
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The Putative Role of Viruses, Bacteria, and Chronic Fungal Biotoxin Exposure in the Genesis of Intractable Fatigue Accompanied by Cognitive
and Physical Disability. AUTHORS: Morris G, Berk M, Walder K, Maes M. SOURCE: Mol Neurobiol. 2015 Jun 17.
The Relationship between Tourette’s Syndrome and Infections AUTHORS: Krause D L, Norbert Müller N SOURCE: The Open Neurology
Journal, 2012, 6, (Suppl 1-M8) 124-128 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514747/pdf/TONEUJ-6-124.pdf
The underdiagnosis of neuropsychiatric Lyme disease in children and adults. AUTHORS: Fallon BA, Kochevar J, Nields J. SOURCE: In
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Tick-Borne Encephalitis Carries a High Risk of Incomplete Recovery in Children. AUTHORS: Fowler A, Forsman L, Eriksson M, Wickstrom
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Tick-borne infections--a growing public health threat to school-age children. Prevention steps that school personnel can take. AUTHOR: Hamlen
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Transfection "Junk" DNA - a link to the pathogenesis of Alzheimer's disease? AUTHORS: MacDonald AB. SOURCE: Med Hypotheses.
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Treating Depression and Compensatory Narcissistic Personality Style in a Man with Chronic Lyme Disease. AUTHOR: Leedy MJ, Jackson M,
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Treatment of patients with persistent symptoms and a history of Lyme disease. AUTHORS: Bransfield R, Brand S, Sherr V. SOURCE: N Engl J
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Treatment-Resistant Depression: Progress and Limitations. AUTHORS: Amsterdam JD, O’Reardon JP. SOURCE: Psychiatric Annals.
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Tremor, seizures and psychosis as presenting symptoms in a patient with chronic lyme neuroborreliosis (LNB). AUTHORS: Markeljević J,
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Tullio phenomenon and seronegative Lyme borreliosis [letter] AUTHORS: Nields JA, Kueton JF. SOURCE: Lancet 1991 Jul
13;338(8759):128-9
The neuropsychiatric assessment of Lyme disease. AUTHOR: Bransfield, R.. SOURCE: Available online at www.mentalhealthandillness.com
The role of kynurenines in disorders of the central nervous system: Possibilities for neuroprotection. AUTHORS: Vamos E, Pardutz A, Klivenyi
P, Toldi J, Vecsei L.SOURCE: J Neurol Sci. 2009 Mar 4.
The Underdiagnosis of Neuropsychiatric Lyme Disease in Children and Adults AUTHORS: Fallon BA, Kochevar JM, Gaito A, Nields JA.
SOURCE: Psychiatric Clinics of North America, 1998; 21: 693-703 COMPLETE TEXT AT: http://www.lymenet.org
Undiagnosed Lyme disease in adults with schizophrenia. AUTHORS: Koola MM et al. SOURCE: Schizophrenia Research. Published Online:
August 06, 2015. http://dx.doi.org/10.1016/j.schres.2015.06.029
Untreated neuroborreliosis: Bannwarth's syndrome evolving into acute schizophrenia-like psychosis. A case report.AUTHORS: Roelcke U,
Barnett W, Wilder-Smith E, Sigmund D, Hacke W. SOURCE: J Neurol 1992 Mar;239(3):129-31
An unusual presentation of cat scratch encephalitis. AUTHORS: Chan L, Reilly KM, Snyder HS. SOURCE: J Emerg Med. 1995 NovDec;13(6):769-72.
Update on lyme disease: the hidden epidemic. AUTHOR: Savely VR. SOURCE: J Infus Nurs. 2008 Jul-Aug;31(4):236-40.
The use of atypical antipsychotics in the treatment of schizophrenia in North Staffordshire. AUTHORS: Hodgson R, Belgamwar R, Al-tawarah
Y, MacKenzie G. SOURCE: Hum Psychopharmacol. 2005 Mar;20(2):141-7.
Value of clinical symptoms, intrathecal specific antibody production and PCR in CSF in the diagnosis of childhood Lyme neuroborreliosis:
AUTHORS: Issakainen J, Gnehm HE, Lucchini GM, Zbinden R: SOURCE: Klin Padiatr 1996 May-Jun; 208 (3) : 106-109
Wann ist eine Borreliose eine Neuroborreliose? Die Borreliose und ihre neuro-psychiatrischen Symptome. AUTHORS: Lorenz M, Redecker H
SOURCE: (2013) http://www.borreliose-lorenz.de/neuroborreliose.html
WAIS-III and WMS-III performance in chronic Lyme disease. AUTHORS: Keilp JG, Corbera K, Slavov I, Taylor MJ, Sackeim HA, Fallon BA.
SOURCE: J Int Neuropsychol Soc. 2006 Jan;12(1):119-29
A 25-year-old woman with hallucinations, hypersexuality, nightmares, and a rash. AUTHORS: Stein SL, Solvason HB, Biggart E, Spiegel D.
SOURCE: Am J Psychiatry. 1996 Apr;153(4):545-51.
A 58-year-old man with a diagnosis of chronic Lyme disease, 1 year later. AUTHOR: Steere AC. SOURCE JAMA. 2002 Aug 28;288(8):1002-
10.
A 58-year-old man with a diagnosis of chronic Lyme disease, 1 year later. AUTHOR Burns RB, Hartman EE. SOURCE JAMA. 2003 Dec
24;290(24):3247.
Additional Articles:
Aggression and Lyme Disease, Bransfield R.
All In Your Head? Bransfield R.
A Tale of Two Spirochetes, Bransfield R.
Lyme Disease and Cognitive Impairments, Bransfield R.
Lyme, Depression, and Suicide, Bransfield R.
Lyme Neuroborreliosis and Aggression, Bransfield RC.
14th International Scientific Conference on Lyme Disease and Other Tick-Borne Disorder. April 21-23, 2001
Microbes and Mental Illness, Bransfield R.
Posttraumatic Stress Disorder and Infectious Encephalopathies, Bransfield R.
Sex and Lyme Disease, Bransfield R.
Spirochetes on the Brain, Bransfield R.
The Klempner Article, Bransfield R. Brand R.
The Lyme-Autism Connection: Unveiling the Shocking Link Between
Lyme Disease and Childhood Developmental Disorders. Duncan T, Rosner B (2008)
http://www.amazon.com/gp/product/0976379759?ie=UTF8&tag=lymeinfo-
20&linkCode=as2&camp=1789&creative=9325&creativeASIN=0976379759
The Neuropsychiatric Assessment of Lyme Disease. Bransfield R.
www.mentalhealthandillness.com/tnaold.html http://www.anapsid.org/lyme/bransfield-neuropsych.pdf
The Psychotropic Management of Late-Stage Lyme and Associated Diseases. Bransfield R.
What Causes Illness and Mental Illness? Bransfield R.
Some of the above references and additional articles are also listed online at:
Neuropsychiatric Lyme Disease Online Resources: http://www.lymeinfo.net/neuropsych.html
And Cavete Diagnosen (Cavete, lat.: hütet euch davor, d.h. hier: vor diesen Diagnosen): http://www.erlebnishaft.de/cavete_diagnosen.pdf
http://www.erlebnishaft.de/kommentalternativ.pdf Compiled by Robert Bransfield, MD, DLFAPA, Rutgers, RWJ Medical School, September
2015
Tick-Borne Diseases and Dementia
This list is organized by date.
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• Macdonald AB. Transfection ‘‘Junk’’ DNA – A link to the pathogenesis of Alzheimer’s disease? Medical Hypothesis. 2006 30
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• Miklossy J, Van der Loos H. (1991) The long distance effects of brain lesions: A study of myelinated pathways in the human brain
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• McLaughlin R, Kin NM, Chen MF, et al. (1999) Alzheimer's disease may not be a spirochetosis. Neuroreport 10(7), 1489-91.
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November 2012, http://www.Huismans.de.vu
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